CNS metastases in women with secondary breast cancer

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• Background
• Clinical practice recommendations and practice points
• Statements of evidence
  • Evidence from trial or study results
    • Evidence from trial or study results: surgery
    • Evidence from trial or study results: radiotherapy
    • Evidence from trial or study results: systemic therapies
    • Evidence from trial or study results: multimodal treatment
    • Evidence from trial or study results: asymptomatic patients
    • Evidence from trial or study results: spinal cord compression
  • Supporting information for practice points
    • Supporting information for practice points: surgery
  • Strengths and weakness of the evidence
  • Unanswered questions
• International guidelines
• Ongoing and additional trials
• Information for women and their families and carers
• References
• Acknowledgements
• Guideline development process
• Additional information
• Appendix 1: grading the recommendations
• Appendix 2: evidence statements for grading the recommendations