Book traversal links for Depression and anxiety: Hormonal interventions
Menopause hormone therapy
One RCT (with a high risk of bias) in women after breast cancer found a statistically significant improvement for both depression and anxiety in the menopause hormone therapy group (oestradiol ± progestogen) at 6 and 12 months compared with baseline. In the no treatment group there was a statistically significant improvement in anxiety at 12 months compared to baseline. Between group differences were not reported.78
One RCT (with a low risk of bias) in women after breast cancer found no statistically significant difference in anxiety for tibolone (2.5mg/d for a mean of 2.5 years) compared with placebo.35