Skip to main content

Treatment options

Vaginal cancer treatment options include surgery, radiation therapy, and chemotherapy, with specific choices depending on cancer stage, spread, general health, and personal preferences.

Treatment and care of people with cancer is usually provided by a team of health professionals, including doctors, nurses and allied health professionals, called a multidisciplinary team.  

Treatment for vaginal cancer depends on: 

  • the type of vaginal cancer 
  • whether the cancer has spread, and where it has spread to 
  • your general health 
  • your personal preferences. 

Treatment options include surgery, chemotherapy and radiation therapy. 

Surgery

Stage 1 or 2 vaginal cancer is often removed during surgery. The type of surgery you will have depends on the size and position of the cancer. 

It may be possible to just remove the cancer and some of the surrounding normal tissue.  

Surgery for vaginal cancer can affect many aspects of your life including sexuality and intimacy. See Living with vaginal cancer for more information. 

Vaginectomy

Some women may need to have a larger operation that removes all the vagina (vaginectomy). Sometimes it is possible to make a new vagina (vaginal reconstruction) using tissue from other parts of the body. 

Radical hysterectomy

It may also be necessary to remove the uterus (womb), cervix, ovaries and fallopian tubes. This operation is called a radical hysterectomy. During this operation, some of the lymph nodes in the pelvis may also be removed. You may have to spend about a week in hospital. 

Lymphadenectomy (lymph node dissection)

Lymph node dissection is a surgical procedure in which lymph nodes are removed and checked under a microscope for signs of cancer. If the cancer is in the upper vagina, the pelvic lymph nodes may be removed. If the cancer is in the lower vagina, lymph nodes in the groin may be removed. 

Pelvic exenteration

Pelvic exenteration is usually only used for recurrent vaginal cancer that has come back even after radiation therapy.1 

Pelvic exenteration is surgery to remove the lower colon, rectum and bladder. In women, the cervix, vagina, ovaries and nearby lymph nodes are also removed. Openings called stoma are made to bring the small or large intestine out onto the abdomen. This allows urine and faeces to flow from inside the body to a collection bag. 

Common stoma include: 

  • an ileostomy (formed from the lower half of the small bowel, called the ileum, which joins up with the colon) 
  • a colostomy (formed from the colon) 
  • an ideal conduit (formed by isolating a small piece of ileum and implanting the tubes from the kidney – the ureters – into it).  

For more information about adapting to life with a stoma, ask your treatment team or contact your local stoma association. 

Plastic surgery to reconstruct the vagina may also be needed after pelvic exenteration. 

Radiation therapy

Radiation therapy is a commonly used treatment for vaginal cancer. In some women, radiation therapy may be combined with chemotherapy. 

You might have external radiation therapy to your pelvic area to treat vaginal cancer. Radiation therapy may also be recommended if the cancer has come back or spread (recurrent cancer). 

You may also have a type of radiation therapy called vaginal brachytherapy. This is when a source of radiation is placed in your vagina, like a tampon. This allows the radiation treatment to target the area more precisely. 

Chemotherapy

In women with vaginal cancer, chemotherapy is mainly used if the cancer is advanced, or if the cancer returns after treatment. It may also be used with radiation therapy before surgery to help shrink the tumour. 

Recurrent or advanced disease

Recurrent vaginal cancer is cancer that has recurred (come back) after it has been treated. 

Metastatic cancer, also known as advanced or secondary cancer, is when the cancer spreads to another part of the body.  

Vaginal cancer may come back in the vagina, the pelvis or elsewhere in the body. 

Treatment of recurrent vaginal cancer may include the following: 

Treating vaginal intraepithelial neoplasia (VAIN)

Not all VAIN needs to be treated. The decision to treat will depend on several factors, including if a woman is considered to be at high risk of vaginal cancer. 

VAIN that has not spread far may not require any treatment. To recommend no treatment, a gynaecologist needs to be sure that there isn’t an underlying malignancy in the VAIN tissue. 

Surgically removing the abnormal tissue is an option, but involves some risk of complications and can affect sexual function. 

Destroying the VAIN with laser treatment or heat treatment (loop diathermy) has fewer side effects. However, if the VAIN is at high risk of developing into cancer, surgery may be safer and give greater peace of mind. 

Anti-cancer chemotherapy topical creams are also sometimes prescribed. Although these are effective, they can cause discomfort and inflammation. 

Occasionally, VAIN is so widespread or hard to treat that more extensive surgery or radiotherapy is recommended. 

Cancer Australia

Cancer Australia was established by the Australian Government in 2006 to benefit all Australians affected by cancer, and their families and carers. Cancer Australia aims to reduce the impact of cancer, address disparities and improve outcomes for people affected by cancer by leading and coordinating national, evidence-based interventions across the continuum of care.

If you would like an interpreter to help you understand any information on this website, please call TIS National on 131 450 and ask them to call Cancer Australia on 02 9357 9400. Our business hours are 9am to 5pm, Monday to Friday.

© 2025 Cancer Australia. All rights reserved.