Mental health: Pharmacological interventions

Antidepressants

Three RCTs (with a moderate risk of bias) in women after breast cancer found no statistically significant differences in mental health between the SNRI venlafaxine (37.5mg/d or 75mg/d) and placebo,21clonidine (0.05mg/d),22 and gabapentin (900mg/d).24 Another RCT (with a moderate risk of bias) found an equivalent statistically significant improvement in mental health and menopause-specific quality of life for venlafaxine (75mg/d) and acupuncture (30min/twice a week).25

Anticonvulsants

One RCT (with a moderate risk of bias) in women after breast cancer found a significant improvement in mental health for gabapentin (900mg/d) compared with baseline, but found no statistically significant improvement for vitamin E (800IU/d) compared with baseline. The study did not report change from baseline between group differences.33