Assessment algorithm

FRA-BOC Assertion definitions

Evaluation Categories

Category 1
  • At or slightly above average risk of breast cancer
  • At average risk of ovarian cancer
Category 2
  • Moderately increased risk of breast cancer
  • If ovarian cancer is not present in highest risk side of the family
    - At average risk of ovarian cancer
  • If ovarian cancer is present in highest risk side of the family
    - At moderately increased risk of ovarian cancer
Category 3
  • Potentially high risk of breast cancer
  • Potentially high risk of ovarian cancer

Evaluation scenarios

Incidence of ovarian cancer in an identical twin
Category 3 [IA]
Incidence of breast cancer in an identical twin
Category 3 [IB]
A high risk gene fault was shown not to be present in the woman
Category 1 [GA]
A high risk gene fault was shown to be present in the woman
Category 3 [GB]
A high risk gene fault was shown to be present in the woman's family
Category 3 [GC]

Please note all following scenarios are derived from incidences on a single side of the family, i.e. they fall in set MB or set FB.

M - mother's side
eg mother, mother's father etc
F - father's side
eg father, father's mother etc
B (both)
eg siblings, nephews, nieces etc
No Ashkenazi Jewish ancestry - 0 Breast, 0 Ovarian
Category 1 [BB]
No Ashkenazi Jewish ancestry - 1 Breast, 0 Ovarian
Distance of relation At least 1 breast before 40 in female At least 1 breast 41-49 in female Breast 50/Older/don't know in female Breast cancer in a male at any age
1 breast (unilateral breast cancer), 0 ovarian
1st degree Category 2 [NF] Category 2 [NE1] Category 1 [ND1] Category 1 [NA2]
2nd degree Category 1 [NC1] Category 1 [NC1] Category 1 [NC1] Category 1 [NA1]
1 breast (bilateral breast cancer), 0 ovarian
1st degree Category 3 [NG] Category 3 [NE2] Category 2 [ND2] Category 3 [NA3]
2nd degree Category 2 [NC2] Category 2 [NC2] Category 2 [NC2] Category 1 [NA1]
No Ashkenazi Jewish ancestry - 2 Breast, 0 Ovarian
Distance of relation At least 1 breast before 40 in female At least 1 breast 41-49 in female Breast 50/Older/don't know in female Breast cancer in a male at any age
2 breast (unilateral breast cancer), 0 ovarian
2 x 1° Category 3 [NI] Category 2 [NJ] Category 2 [NK] Category 3 [NB]
1 x 1°, 1 x 2° Category 3 [NI] Category 2 [NJ] Category 2 [NL1] Category 3 [NB]
2 x 2° Category 3 [NI] Category 2 [NJ] Category 1 [NL2] Category 3 [NB]
2 breast (1 x unilateral, 1 x bilateral breast cancer), 0 ovarian
1° or 2° Category 3 [NH] Category 3 [NH] Category 3 [NH] Category 3 [NB]
2 breast (2 x bilateral breast cancer), 0 ovarian
1° or 2° Category 3 [NH] Category 3 [NH] Category 3 [NH] Category 3 [NB]
No Ashkenazi Jewish ancestry - 0 or more Breast, 0 or more Ovarian
Category 3 [BD]
No Ashkenazi Jewish ancestry - 0 Breast, 1 Ovarian
Category 1 [NU]
No Ashkenazi Jewish ancestry - 1 Breast, 1 Ovarian
Distance of relation At least 1 breast before 40 in female At least 1 breast 41-49 in female Breast 50/Older/don't know in female Breast cancer in a male at any age
1 breast (unilateral breast cancer), 1 ovarian
1° or 2° Category 3 [NO] Category 3 [NO] Category 2 [NP] Category 3 [NM]
1 breast (bilateral breast cancer), 1 ovarian
1° or 2° Category 3 [NN] Category 3 [NN] Category 3 [NN] Category 3 [NM]
1 breast and ovarian in the same woman
Category 3 [NQ] Category 3 [NQ] Category 2 [NR] n/a
Category 2 [NS] Category 2 [NT] Category 2 [NT] n/a
No Ashkenazi Jewish ancestry - 2 Breast, 1 Ovarian
Category 3 [BE]
No Ashkenazi Jewish ancestry - 0 or more Breast, 2 or more Ovarian
Category 3 [BA]
With Ashkenazi Jewish ancestry - 0 Breast, 0 Ovarian
Category 1 [BB]
With Ashkenazi Jewish ancestry - 1 Breast, 0 Ovarian
Distance of relation At least 1 breast before 40 in female At least 1 breast 41-49 in female Breast 50/Older/don't know in female Breast cancer in a male at any age
1 breast (unilateral breast cancer), 0 ovarian
1st degree Category 3 [WD] Category 2 [WL] Category 2 [WJ] Category 3 [WG1]
2nd degree Category 2 [WE] Category 2 [WM] Category 1 [WF1] Category 2 [WG2]
1 breast (bilateral breast cancer), 0 ovarian
1st degree Category 3 [WD] Category 3 [WN] Category 3 [WK] Category 3 [WG1]
2nd degree Category 2 [WE] Category 2 [WO] Category 2 [WF2] Category 2 [WG2]
With Ashkenazi Jewish ancestry - 2 Breast, 0 Ovarian
Category 3 [WA]
With Ashkenazi Jewish ancestry - 3 or more Breast, 0 or more Ovarian
Category 3 [BD]
With Ashkenazi Jewish ancestry - 0 Breast, 1 Ovarian
Category 3 [WP]
With Ashkenazi Jewish ancestry - 1 Breast, 1 or more Ovarian
Category 3 [WB]
With Ashkenazi Jewish ancestry - 2 Breast, 1 or more Ovarian
Category 3 [BE]
With Ashkenazi Jewish ancestry - 0 or more Breast, 2 or more Ovarian
Category 3 [BA]

 

*In July 2011, National Breast and Ovarian Cancer Centre (NBOCC) amalgamated with Cancer Australia to form a single national agency, Cancer Australia, to provide leadership in cancer control and improve outcomes for Australians affected by cancer.