Loading cart

What does the pathology report mean?

The pathology report contains information about a woman’s breast cancer that helps when making treatment recommendations.

The pathology report contains information about a woman’s breast cancer that helps when making treatment recommendations.

Some of the information in the pathology report will only be available after breast surgery or surgery to the armpit. The pathology report usually includes the following information:

Size and location

The report shows the size of the breast cancer and where it is in the breast. This will affect what treatments are recommended, including the type of surgery.

Hormone receptors

The report shows whether breast cancer is positive or negative for hormone receptors. About two-thirds of women with breast cancer have hormone receptor-positive breast cancer. This will affect whether hormonal therapies are recommended.

HER2 status

The report shows whether there are HER2 receptors on the breast cancer. This is called the HER2 status and will affect whether targeted therapies such as trastuzumab (Herceptin®) are recommended. About one in five women with breast cancer have HER2-positive breast cancer.

Lymph nodes

The report shows whether there are cancer cells in the lymph nodes in the armpit (axilla) or near the breast. This information will usually only be available after surgery to the armpit and may affect whether chemotherapy is recommended.

Surgical margin

During breast conserving surgery, the surgeon removes the breast cancer and an area of healthy looking tissue around the cancer. The healthy looking tissue is called the surgical margin. If there are no cancer cells in the surgical margin, it’s likely that all the cancer has been removed. In this case, the surgical margin is said to be ‘clear’. If the surgical margin is not considered to be ‘clear’, more surgery may be required to ensure that all of the cancer is removed.

Grade of breast cancer

The grade of the breast cancer shows how fast the cancer cells are growing. The cancer grade is numbered from 1 to 3. A low grade (Grade 1) means that the cancer is growing slowly. A high grade (Grade 3 means that the cancer is growing more quickly.

The higher the grade means the cancer is more active. This means it’s more likely the cancer has spread outside the breast and armpit area. The higher grade means that it’s more likely that systemic treatments (treatments that affect the whole body, such as chemotherapy, hormonal therapies and targeted therapies) will be recommended.